COMPARISON OF 5-FLUOROURACIL, DOXORUBICIN AND MITOMYCIN-C WITH 5-FLUOROURACIL ALONE IN THE TREATMENT OF PANCREATIC-BILIARY CARCINOMAS

被引：0

作者：

TAKADA, T

KATO, H

MATSUSHIRO, T

NIMURA, Y

NAGAKAWA, T

NAKAYAMA, T

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT SURG 2,HAKODATE,HOKKAIDO,JAPAN

[2] TOHOKU ROSAI HOSP,DEPT SURG,SENDAI,JAPAN

[3] NAGOYA UNIV,SCH MED,DEPT SURG 1,NAGOYA,AICHI 461,JAPAN

[4] KANAZAWA UNIV,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA,JAPAN

[5] KURUME UNIV,SCH MED,DEPT SURG 2,KURUME,FUKUOKA 830,JAPAN

来源：

ONCOLOGY | 1994年 / 51卷 / 05期

关键词：

PANCREATIC CARCINOMA; BILIARY TRACT CARCINOMA; CHEMOTHERAPY; COMBINATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this multicenter randomized trial, the efficacy of combination chemotherapy using 5-fluorouracil, doxorubicin and mitomycin C (arm A) was compared with that of 5-fluorouracil alone (arm B) in 81 patients with nonresectable carcinomas of the pancreas or biliary tract. There were no significant differences between treatment arms regarding the median time to progressive disease, median survival time, palliative effects or toxicities. It was concluded that combination chemotherapy is feasible but cannot be recommended.

引用

页码：396 / 400

页数：5

共 24 条

[1]

BUKOWSKI RM, 1982, CANCER-AM CANCER SOC, V50, P197, DOI 10.1002/1097-0142(19820715)50:2<197::AID-CNCR2820500204>3.0.CO

[2]

2-N

[3]

CULLINAN S, 1990, CANCER, V65, P2207, DOI 10.1002/1097-0142(19900515)65:10<2207::AID-CNCR2820651007>3.0.CO

[4]

2-Y

[5] A COMPARISON OF 3 CHEMOTHERAPEUTIC REGIMENS IN THE TREATMENT OF ADVANCED PANCREATIC AND GASTRIC-CARCINOMA - FLUOROURACIL VS FLUOROURACIL AND DOXORUBICIN VS FLUOROURACIL, DOXORUBICIN, AND MITOMYCIN [J].

CULLINAN, SA ;

MOERTEL, CG ;

FLEMING, TR ;

RUBIN, JR ;

KROOK, JE ;

EVERSON, LK ;

WINDSCHITL, HE ;

TWITO, DI ;

MARSCHKE, RF ;

FOLEY, JF ;

PFEIFLE, DM ;

BARLOW, JF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 253 (14) :2061-2067

[6] FLUOROURACIL AND HIGH-DOSE LEUCOVORIN IN PREVIOUSLY UNTREATED PATIENTS WITH ADVANCED ADENOCARCINOMA OF THE PANCREAS - RESULTS OF A PHASE-II TRIAL [J].

DECAPRIO, JA ;

MAYER, RJ ;

GONIN, R ;

ARBUCK, SG .

JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (12) :2128-2133

[7]

FALKSON G, 1984, CANCER, V54, P965, DOI 10.1002/1097-0142(19840915)54:6<965::AID-CNCR2820540603>3.0.CO

[8]

2-X

[9] CONTINUOUS 5-FLUOROURACIL (5FU) INFUSION IN CARCINOMA OF THE PANCREAS - A PHASE-II STUDY [J].

HANSEN, R ;

QUEBBEMAN, E ;

RITCH, P ;

CHITAMBAR, C ;

ANDERSON, T .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1988, 295 (02) :91-93

[10] NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].

KAPLAN, EL ;

MEIER, P .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481

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