EFFECT OF NITECAPONE AND CLORGYLINE, GIVEN INTRACEREBRO-VENTRICULARLY ON L-DOPA METABOLISM IN THE RAT-BRAIN

被引：0

作者：

MANNISTO, PT ^{[1
]}

TORNWALL, M ^{[1
]}

TUOMAINEN, P ^{[1
]}

BORISENKO, SA ^{[1
]}

TUOMINEN, RK ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI, INST PHARMACOL, MOSCOW, USSR

来源：

NEUROREPORT | 1992年 / 3卷 / 07期

关键词：

NITECAPONE; CLORGYLINE; INTRACEREBROVENTRICULAR; CATECHOL-O-METHYLTRANSFERASE (COMT); MONOAMINE OXIDASE (MAO); INHIBITORS; L-DOPA; METABOLISM;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A NEW COMT inhibitor, nitecapone (OR-462) or clorgyline, a MAO-A inhibitor, was infused into the 3rd brain ventricle (i.c.v.) of conscious male rats. None of the enzyme inhibitors given alone alter hypothalamic or striatal levels Of L-dopa, dopamine or their metabolites. Most of the rats were pretreated with levodopa/carbidopa (LD/CD, 15/30 mg kg-1 intraperitoneally). Now, the action of nitecapone is localized in the hypothalamus since homovanillic acid (HVA) is decreased there, not in the striatum. The levels of 3-O-methyldopa (3-OMD) are not changed in either brain region, suggesting a lack of the peripheral leakage of nitecapone. Clorgyline (3 and 10 mu-g rat-1) elevates hypothalamic and dopamine levels. Nitecapone and cloryline decrease prolactin (PRL) levels below those reduced by LD/CD treatment.

引用

页码：641 / 644

页数：4

共 24 条

[1] SYNTHESIS OF SOME NOVEL POTENT AND SELECTIVE CATECHOL O-METHYLTRANSFERASE INHIBITORS [J].