Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

被引：14

作者：

Ishibashi, Masaya ^{[1
]}

Fujimura, Taku ^{[1
]}

Hashimoto, Akira ^{[1
]}

Haga, Takahiro ^{[1
]}

Onami, Kaoru ^{[1
]}

Tsukada, Akira ^{[1
]}

Kambayashi, Yumi ^{[1
]}

Hidaka, Takanori ^{[1
]}

Furudate, Sadanori ^{[1
]}

Shimada, Ryoko ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan

来源：

CASE REPORTS IN DERMATOLOGY | 2012年 / 4卷 / 01期

关键词：

Angiosarcoma; MMP-9; Bisphosphonate; Docetaxel;

D O I：

10.1159/000335999

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

引用

页码：5 / 9

页数：5

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