A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

被引：2

作者：

Nishiuma, Teruaki ^{[1
,2
]}

Ohnishi, Hisashi ^{[1
]}

Yoshimura, Sho ^{[1
]}

Kinami, Saori ^{[3
]}

Sakamoto, Susumu ^{[3
]}

机构：

[1] Akashi Med Ctr, Dept Resp Med, 743-33 Yagi,Okubo Cho, Akashi, Hyogo 6740063, Japan

[2] Kakogawa West City Hosp, Dept Resp Med, Kakogawa, Hyogo 6758611, Japan

[3] Akashi Med Ctr, Dept Internal Med, Akashi, Hyogo 6740063, Japan

来源：

CASE REPORTS IN MEDICINE | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/208194

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.

引用

页数：5

共 17 条

[1] Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies [J].

Chen, M ;

Yu, F ;

Zhang, Y ;

Zou, WZ ;

Zhao, MH ;

Wang, HY .

KIDNEY INTERNATIONAL, 2005, 68 (05) :2225-2229

[2] PULMONARY WEGENERS GRANULOMATOSIS - A CLINICAL AND IMAGING STUDY OF 77 CASES [J].

CORDIER, JF ;

VALEYRE, D ;

GUILLEVIN, L ;

LOIRE, R ;

BRECHOT, JM .

CHEST, 1990, 97 (04) :906-912

[3] TRACHEOBRONCHIAL INVOLVEMENT IN WEGENERS GRANULOMATOSIS [J].

DAUM, TE ;

SPECKS, U ;

COLBY, TV ;

EDELL, ES ;

BRUTINEL, MW ;

PRAKASH, UBS ;

DEREMEE, RA .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 151 (02) :522-526

[4] Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the UK [J].

Fujimoto, Shouichi ;

Watts, Richard A. ;

Kobayashi, Shigeto ;

Suzuki, Kazuo ;

Jayne, David R. W. ;

Scott, David G. I. ;

Hashimoto, Hiroshi ;

Nunoi, Hiroyuki .

RHEUMATOLOGY, 2011, 50 (10) :1916-1920

[5] 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides [J].

Jennette, J. C. ;

Falk, R. J. ;

Bacon, P. A. ;

Basu, N. ;

Cid, M. C. ;

Ferrario, F. ;

Flores-Suarez, L. F. ;

Gross, W. L. ;

Guillevin, L. ;

Hagen, E. C. ;

Hoffman, G. S. ;

Jayne, D. R. ;

Kallenberg, C. G. M. ;

Lamprecht, P. ;

Langford, C. A. ;

Luqmani, R. A. ;

Mahr, A. D. ;

Matteson, E. L. ;

Merkel, P. A. ;

Ozen, S. ;

Pusey, C. D. ;

Rasmussen, N. ;

Rees, A. J. ;

Scott, D. G. I. ;

Specks, U. ;

Stone, J. H. ;

Takahashi, K. ;

Watts, R. A. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (01) :1-11

[6] Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis) [J].

Jennette, J. C. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2011, 164 :7-10

[7] NOMENCLATURE OF SYSTEMIC VASCULITIDES - PROPOSAL OF AN INTERNATIONAL CONSENSUS CONFERENCE [J].

JENNETTE, JC ;

FALK, RJ ;

ANDRASSY, K ;

BACON, PA ;

CHURG, J ;

GROSS, WL ;

HAGEN, EC ;

HOFFMAN, GS ;

HUNDER, GG ;

KALLENBERG, CGM ;

MCCLUSKEY, RT ;

SINICO, RA ;

REES, AJ ;

VANES, LA ;

WALDHERR, R ;

WIIK, A .

ARTHRITIS AND RHEUMATISM, 1994, 37 (02) :187-192

[8] Granuloma formation in ANCA-associated vasculitides [J].

Lamprecht, Peter ;

Wieczorek, Stefan ;

Epplen, Jorg T. ;

Ambrosch, Petra ;

Kallenberg, Cees G. M. .

APMIS, 2009, 117 :32-36

[9] Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients [J].

Lee, KS ;

Kim, TS ;

Fujimoto, K ;

Moriya, H ;

Watanabe, H ;

Tateishi, U ;

Ashizawa, K ;

Johkoh, T ;

Kim, EA ;

Kwon, OJ .

EUROPEAN RADIOLOGY, 2003, 13 (01) :43-51

[10] EULAR recommendations for the management of primary small and medium vessel vasculitis [J].

Mukhtyar, C. ;

Guillevin, L. ;

Cid, M. C. ;

Dasgupta, B. ;

de Groot, K. ;

Gross, W. ;

Hauser, T. ;

Hellmich, B. ;

Jayne, D. ;

Kallenberg, C. G. M. ;

Merkel, P. A. ;

Raspe, H. ;

Salvarani, C. ;

Scott, D. G. I. ;

Stegeman, C. ;

Watts, R. ;

Westman, K. ;

Witter, J. ;

Yazici, H. ;

Luqmani, R. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (03) :310-317

← 1 2 →