A VACCINIA VIRUS HERPES-SIMPLEX VIRUS (HSV) GLYCOPROTEIN B1 RECOMBINANT OR AN HSV VACCINE OVERCOME THE HSV TYPE-2 INDUCED HUMORAL IMMUNOSUPPRESSION AND PROTECT AGAINST VAGINAL CHALLENGE IN BALB/C MICE

被引：6

作者：

FLECK, M ^{[1
]}

PODLECH, J ^{[1
]}

WEISE, K ^{[1
]}

FALKE, D ^{[1
]}

机构：

[1] INST MED MICROBIOL,DIV EXPTL VIROL,D-55101 MAINZ,GERMANY

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 1994年 / 183卷 / 02期

关键词：

D O I：

10.1007/BF00277159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary infections with herpes simplex virus type 2 (HSV-2) suppress the antibody response to secondary HSV-1 and -2 infections in the BALB/c mouse. In contrast, a challenge by the i.p. route using a vaccinia virus-HSV-1 glycoprotein B (VV gB 1) recombinant induces a significant enhancement of the antibody response. This booster reaction is also observed if a challenge with a formalin-inactivated HSV-1 vaccine is performed. Although no or low humoral and vaginal antibodies are detectable after a single i.p. infection with the VV gB1 recombinant or the HSV-1 vaccine, protection against vaginal challenge with HSV-2 is induced. This points to the important role of cellular immunity for vaginal infections.

引用

页码：87 / 94

页数：8

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[41] EFFECTOR MECHANISMS IN THE INDUCED RESISTANCE AGAINST LETHAL HERPES-SIMPLEX TYPE-2 (HSV2) INFECTIONS IN MICE
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[J]. ZEITSCHRIFT FUR IMMUNITATSFORSCHUNG-IMMUNOBIOLOGY, 1979, 156 (03): : 201 - 201
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