SYSTEMATIC DETECTION OF ERRORS IN GENETIC-LINKAGE DATA

被引：294

作者：

LINCOLN, SE

LANDER, ES

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02142

[2] MIT,CTR GENOME RES,CAMBRIDGE,MA 02142

来源：

GENOMICS | 1992年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0888-7543(05)80158-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Construction of dense genetic linkage maps is hampered, in practice, by the occurrence of laboratory typing errors. Even relatively low error rates cause substantial map expansion and interfere with the determination of correct genetic order. Here, we describe a systematic method for overcoming these difficulties, based on incorporating the possibility of error into the usual likelihood model for linkage analysis. Using this approach, it is possible to construct genetic maps allowing for error and to identify the typings most likely to be in error. The method has been implemented for F2 intercrosses between two inbred strains, a situation relevant to the construction of genetic maps in experimental organisms. Tests involving both simulated and real data are presented, showing that the method detects the vast majority of errors. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：604 / 610

页数：7

共 14 条

[1]

BOTSTEIN D, 1980, AM J HUM GENET, V32, P314

[2]

BUETOW KH, 1991, AM J HUM GENET, V49, P985

[3]

CHAKRAVARTI A, 1992, UNPUB ESTIMATION CHR

[4] DEVELOPMENT AND APPLICATIONS OF A MOLECULAR GENETIC-LINKAGE MAP OF THE MOUSE GENOME [J].

COPELAND, NG ;

JENKINS, NA .

TRENDS IN GENETICS, 1991, 7 (04) :113-118

[5]

DIETRICH W, 1992, GENETICS, V131, P423

[6] A GENETIC-LINKAGE MAP OF THE HUMAN GENOME [J].

DONISKELLER, H ;

GREEN, P ;

HELMS, C ;

CARTINHOUR, S ;

WEIFFENBACH, B ;

STEPHENS, K ;

KEITH, TP ;

BOWDEN, DW ;

SMITH, DR ;

LANDER, ES ;

BOTSTEIN, D ;

AKOTS, G ;

REDIKER, KS ;

GRAVIUS, T ;

BROWN, VA ;

RISING, MB ;

PARKER, C ;

POWERS, JA ;

WATT, DE ;

KAUFFMAN, ER ;

BRICKER, A ;

PHIPPS, P ;

MULLERKAHLE, H ;

FULTON, TR ;

NG, S ;

SCHUMM, JW ;

BRAMAN, JC ;

KNOWLTON, RG ;

BARKER, DF ;

CROOKS, SM ;

LINCOLN, SE ;

DALY, MJ ;

ABRAHAMSON, J .

CELL, 1987, 51 (02) :319-337

[7] THE CEPH1 CONSORTIUM LINKAGE MAP OF HUMAN CHROMOSOME-1 [J].

DRACOPOLI, NC ;

OCONNELL, P ;

ELSNER, TI ;

LALOUEL, JM ;

WHITE, RL ;

BUETOW, KH ;

NISHIMURA, DY ;

MURRAY, JC ;

HELMS, C ;

MISHRA, SK ;

DONISKELLER, H ;

HALL, JM ;

LEE, MK ;

KING, MC ;

ATTWOOD, J ;

MORTON, NE ;

ROBSON, EB ;

MAHTANI, M ;

WILLARD, HF ;

ROYLE, NJ ;

PATEL, I ;

JEFFREYS, AJ ;

VERGA, V ;

JENKINS, T ;

WEBER, JL ;

MITCHELL, AL ;

BALE, AE .

GENOMICS, 1991, 9 (04) :686-700

[8] STOCHASTIC RELAXATION, GIBBS DISTRIBUTIONS, AND THE BAYESIAN RESTORATION OF IMAGES [J].

GEMAN, S ;

GEMAN, D .

IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 1984, 6 (06) :721-741

[9]

LANDER E S, 1987, Genomics, V1, P174, DOI 10.1016/0888-7543(87)90010-3

[10] CONSTRUCTION OF MULTILOCUS GENETIC-LINKAGE MAPS IN HUMANS [J].

LANDER, ES ;

GREEN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2363-2367

← 1 2 →