SYNTHESIS AND CNS-ACTIVITY OF PYRAN DERIVATIVES - 6,8-DIOXABICYCLO[3,2,1]OCTANES .133.

被引：134

作者：

EIDEN, F

DENK, F

机构：

[1] Institut für Pharmazie und Lebensmittelchemie, Universität München, München, 8000

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 06期

关键词：

D O I：

10.1002/ardp.19913240606

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The amino nitriles 4a,b and 5a,b, prepared from (1S,5R)-6,8-dioxabicyclo[3,2,1]octan-4-one (2), react with phenylmagnesium bromide to afford the diastereomeric 4-amino-4-phenyl derivatives 7a,b and 8a,b, respectively. The diastereomeric piperidine derivatives 7b and 8b show different CNS-activity.

引用

页码：353 / 354

页数：2

共 10 条

[1] BRUYLANTS P, 1924, B SOC CHIM BELG, V33, P476
[2] Bruylants P., 1926, B SOC CHIM BELG, V35, P139
[3] PYRAN DERIVATIVES .128. CNS-ACTIVE 4-PHENYL-PYRANS - SYNTHESIS AND REACTIONS OF 4-PHENYL-2-PIPERIDINO-DIHYDROPYRAN CARBOXYLIC ESTERS
EIDEN, F
ECKLE, A
[J]. ARCHIV DER PHARMAZIE, 1989, 322 (10) : 617 - 627
[4] 5,6-DIHYDRO-6-METHOXY-2H-PYRANE-3(4H)-ONE, A BUILDING BLOCK FOR THE SYNTHESES OF CNS-AGENTS .131.
EIDEN, F
WUNSCH, B
[J]. ARCHIV DER PHARMAZIE, 1990, 323 (07) : 393 - 399
[5] SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF PHENYL-TETRAHYDROPYRANS AND PHENYL-HIOPYRANS WITH ZNS ACTIVITY - OXA-PHENCYCLIDINES AND THIA-PHENCYCLIDINES
EIDEN, F
SCHMIDT, M
BUCHBORN, H
[J]. ARCHIV DER PHARMAZIE, 1987, 320 (04) : 348 - 361
[6] 3-OXIDOPYRYLIUM ADDUCTS FROM THE PYROLYSIS OF CELLULOSE
FURNEAUX, RH
MASON, JM
MILLER, IJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (08): : 1923 - 1928
[7] LEVOGLUCOSENONE (1,6-ANHYDRO-3,4-DIDEOXY-DELTA3-BETA-D-PYRANOSEN-2-ONE) - MAJOR PRODUCT OF ACID-CATALYZED PYROLYSIS OF CELLULOSE AND RELATED CARBOHYDRATES
HALPERN, Y
RIFFER, R
BROIDO, A
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (02) : 204 - 209
[8] SHAFIZADEH F, 1979, Carbohydrate Research, V71, P169, DOI 10.1016/S0008-6215(00)86069-3
[9] PREPARATION OF 1,6-ANHYDRO-3,4-DIDEOXY-BETA-D-GLYCERO-HEX-3-ENOPYRANOS-2-ULOSE (LEVO-GLUCOSENONE) AND SOME DERIVATIVES THEREOF
SHAFIZADEH, F
CHIN, PPS
[J]. CARBOHYDRATE RESEARCH, 1977, 58 (01) : 79 - 87
[10] STCHEW RJ, 1988, CARBOHYD RES, V174, P161

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