SYNTHESIS AND CNS-ACTIVITY OF PYRAN DERIVATIVES - 6,8-DIOXABICYCLO[3,2,1]OCTANES .133.

被引：135

作者：

EIDEN, F

DENK, F

机构：

[1] Institut für Pharmazie und Lebensmittelchemie, Universität München, München, 8000

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 06期

关键词：

D O I：

10.1002/ardp.19913240606

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The amino nitriles 4a,b and 5a,b, prepared from (1S,5R)-6,8-dioxabicyclo[3,2,1]octan-4-one (2), react with phenylmagnesium bromide to afford the diastereomeric 4-amino-4-phenyl derivatives 7a,b and 8a,b, respectively. The diastereomeric piperidine derivatives 7b and 8b show different CNS-activity.

引用

收藏

页码：353 / 354

页数：2

相关论文

共 10 条

[1]

BRUYLANTS P, 1924, B SOC CHIM BELG, V33, P476

[2]

Bruylants P., 1926, B SOC CHIM BELG, V35, P139

[3] PYRAN DERIVATIVES .128. CNS-ACTIVE 4-PHENYL-PYRANS - SYNTHESIS AND REACTIONS OF 4-PHENYL-2-PIPERIDINO-DIHYDROPYRAN CARBOXYLIC ESTERS [J].

EIDEN, F ;

ECKLE, A .

ARCHIV DER PHARMAZIE, 1989, 322 (10) :617-627

[4] 5,6-DIHYDRO-6-METHOXY-2H-PYRANE-3(4H)-ONE, A BUILDING BLOCK FOR THE SYNTHESES OF CNS-AGENTS .131. [J].

EIDEN, F ;

WUNSCH, B .

ARCHIV DER PHARMAZIE, 1990, 323 (07) :393-399

[5] SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF PHENYL-TETRAHYDROPYRANS AND PHENYL-HIOPYRANS WITH ZNS ACTIVITY - OXA-PHENCYCLIDINES AND THIA-PHENCYCLIDINES [J].

EIDEN, F ;

SCHMIDT, M ;

BUCHBORN, H .

ARCHIV DER PHARMAZIE, 1987, 320 (04) :348-361

[6] 3-OXIDOPYRYLIUM ADDUCTS FROM THE PYROLYSIS OF CELLULOSE [J].

FURNEAUX, RH ;

MASON, JM ;

MILLER, IJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (08) :1923-1928

[7] LEVOGLUCOSENONE (1,6-ANHYDRO-3,4-DIDEOXY-DELTA3-BETA-D-PYRANOSEN-2-ONE) - MAJOR PRODUCT OF ACID-CATALYZED PYROLYSIS OF CELLULOSE AND RELATED CARBOHYDRATES [J].

HALPERN, Y ;

RIFFER, R ;

BROIDO, A .

JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (02) :204-209

[8]

SHAFIZADEH F, 1979, Carbohydrate Research, V71, P169, DOI 10.1016/S0008-6215(00)86069-3

[9] PREPARATION OF 1,6-ANHYDRO-3,4-DIDEOXY-BETA-D-GLYCERO-HEX-3-ENOPYRANOS-2-ULOSE (LEVO-GLUCOSENONE) AND SOME DERIVATIVES THEREOF [J].

SHAFIZADEH, F ;

CHIN, PPS .

CARBOHYDRATE RESEARCH, 1977, 58 (01) :79-87

[10]

STCHEW RJ, 1988, CARBOHYD RES, V174, P161