ETHANOL INHIBITS RELEASE OF EXCITATORY AMINO-ACIDS FROM SLICES OF HIPPOCAMPAL AREA CA1

被引：51
作者：
MARTIN, D
SWARTZWELDER, HS
机构：
[1] DUKE UNIV, MED CTR, DEPT PHARMACOL, DURHAM, NC 27710 USA
[2] DUKE UNIV, MED CTR, DEPT PSYCHOL, DURHAM, NC 27710 USA
[3] DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 03期
关键词：
ASPARTATE RELEASE; GLUTAMATE RELEASE; ETHANOL; HIPPOCAMPUS; GABA (GAMMA-AMINOBUTYRIC ACID);
D O I：
10.1016/0014-2999(92)90491-L
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Slices of hippocampal area CA1 were employed to test the hypothesis that release of excitatory amino acids glutamate and aspartate is regulated by ethanol. K+-evoked release of glutamate and aspartate was inhibited by ethanol (25-100 mM) in a dose-dependent manner. Ethanol (100 mM) also inhibited K+-evoked gamma-aminobutyric acid release. This selective inhibition of excitatory amino acid release by ethanol may contribute to some of the learning and memory deficits associated with ethanol abuse, since excitatory amino acid receptors play an important role in synaptic plasticity processes.
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页码：469 / 472
页数：4
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