THE IMMEDIATE RESULTS OF COMBINATION CHEMOTHERAPY WITH VINCRISTINE, PLATIDIAM AND ADRIAMYCIN FOR ADVANCED AND RECURRENT CERVICAL-CANCER

Thirty patients with advanced or recurrent cervical cancer were given combination chemotherapy including 1 mg/m2 vincristine i. v. on days 1 and 8, 120 mg/m2 i. v. dropwise on day 2 with hydration and forced diuresis and 40 mg/m2 adriamycin on day 9. Treatment courses were repeated every 3-4 weeks. Complete response was observed in 1 (3.3 %) patient, while more than 50 % regression of tumor was obtained in 12 (40 %) patients raising the complete plus partial response rate to as high as 43.3 %. Nausea and vomiting occurred in all the patients, myelosuppression - 60 %, nephrotoxic effect - 40 % and alopecia - in 96.7 % of patients.