INVIVO ANGIOGENIC ACTIVITY OF INTERLEUKINS

被引：99
作者：
BENEZRA, D [1 ]
HEMO, I [1 ]
MAFTZIR, G [1 ]
机构：
[1] HADASSAH UNIV HOSP,PEDIAT & IMMUNOOPHTHALMOL UNIT,IL-91120 JERUSALEM,ISRAEL
来源：
ARCHIVES OF OPHTHALMOLOGY | 1990年 / 108卷 / 04期
关键词：
D O I：
10.1001/archopht.1990.01070060121061
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the “unitarian angiogenic factor”. © 1990, American Medical Association. All rights reserved.
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页码：573 / 576
页数：4
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