Alpha-1 Adrenergic Antagonists Induced Severe Rhinitis in Patients with Benign Prostatic Hyperplasia

被引：2

作者：

Shahar, Eduardo ^{[1
,2
]}

Nassar, Laila ^{[1
]}

Kedem, Eynat ^{[1
,2
]}

Hassoun, Gammal ^{[1
,2
]}

机构：

[1] Inst Allergy Clin Immunol & AIDS, Rambam Hlth Care Campus, Haifa, Israel

[2] Techn Israel Inst Technol, Rappaport Fac Med, Haifa, Israel

来源：

CURRENT DRUG SAFETY | 2014年 / 9卷 / 02期

关键词：

Benign prostatic hyperplasia (BPH); lower urinary tract symptoms (LUTS);

D O I：

10.2174/1574886309666140527112408

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The standard gold care medications for benign prostatic hyperplasia (BPH) are the alpha-1-adrenergic antagonists, they are an effective medications and are generally well tolerated. However, at this time, no data have been published concerning the development of severe rhinorrhea with a great impact on quality of life in patients treated with alpha-1-adrenergic antagonists. We report two men with BPH treated with two different alpha-adrenergic antagonists; alfuzosin and doxazocin. The naranjo quality scale documented a probable adverse drug reaction (score 7) between rhinorrhea and treatmenr with alpha-1-adrenergic antagonists. In conclusion we reported that alpha-1-adrenergic antagonists are able to induce rhinorrhea in patients with BPH.

引用

页码：159 / 160

页数：2

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