APPLICATION OF YEAST-CATALYZED REDUCTIONS TO SYNTHESIS OF (2R,3S)-PHENYLISOSERINE

被引：48

作者：

KEARNS, J ^{[1
]}

KAYSER, MM ^{[1
]}

机构：

[1] UNIV NEW BRUNSWICK,DEPT PHYS SCI,ST JOHN E2L 4L5,NB,CANADA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)76640-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of (2R,3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol(R)(paclitaxel), utilising yeast-catalyzed reduction to generate a second chiral centre is reported. This short enantioselective series of transformations can be readily adapted to large scale production of a variety of N-substituted paclitaxel analogues.

引用

页码：2845 / 2848

页数：4

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