APPLICATION OF YEAST-CATALYZED REDUCTIONS TO SYNTHESIS OF (2R,3S)-PHENYLISOSERINE

被引：48
|
作者：
KEARNS, J [1 ]
KAYSER, MM [1 ]
机构：
[1] UNIV NEW BRUNSWICK,DEPT PHYS SCI,ST JOHN E2L 4L5,NB,CANADA
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 18期
关键词：
D O I：
10.1016/S0040-4039(00)76640-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple synthesis of (2R,3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol(R)(paclitaxel), utilising yeast-catalyzed reduction to generate a second chiral centre is reported. This short enantioselective series of transformations can be readily adapted to large scale production of a variety of N-substituted paclitaxel analogues.
引用
收藏
页码：2845 / 2848
页数：4
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