TRANSFER OF BILIRUBIN COVALENTLY BOUND TO I-125 ALBUMIN FROM BLOOD TO BRAIN IN THE GUNN RAT NEWBORN

被引：0

作者：

OHSUGI, M

SATO, H

YAMAMURA, H

机构：

[1] NAGOYA UNIV,RES INST ENVIRONM MED,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN

[2] MIE UNIV,SCH MED,DEPT ANAT,TSU,MIE 514,JAPAN

[3] SHIGA UNIV MED SCI,DEPT BIOL,OTSU,SHIGA 52021,JAPAN

来源：

BIOLOGY OF THE NEONATE | 1992年 / 62卷 / 06期

关键词：

ALBUMIN-BOUND BILIRUBIN; PLASMA; CEREBELLUM; CEREBRUM; JAUNDICE;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Transfer of bilirubin covalently bound to albumin (Alb.B) from blood into brain was examined in Gunn rats at postnatal day 3, 7, 14, 28 or 70. The ratio of the I-125-Alb.B concentration in the brain to that in the plasma 2 h after the injection (RAB) was used as a criterion for Alb.B transfer. RAB in brain decreased with age until day 28. Significant correlations were indicated between I-125-Alb.B plasma levels and those in the brain at days 7 and 14, but not at day 28. These results suggested that I-125-Alb.B could transfer from the blood to the brain until day 14. Comparison of the relative amount of radioactivity accumulated in the brain by a I-125-Alb.B injection with that of I-125-albumin alone revealed higher radioactivity in the former than the latter only at day 14, suggesting a transient appearance of particular cellular elements with high affinity to bilirubin in the developmental stage of the brain.

引用

页码：416 / 423

页数：8

共 23 条

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