PYRAZIDOLE ENANTIOMERS - PREPARATION AND PHARMACOLOGICAL PROPERTIES

被引：0
|
作者：
ANDREYEVA, NI
BOGDANOVA, GA
BOKANOV, AI
IVANOV, PY
MASHKOVSKY, MD
SHVEDOV, VI
机构：
来源：
KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1992年 / 26卷 / 05期
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中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The asymmetric synthesis of pyrazidole (+)-enantiomer was made. A pyrazidole (-)-enantiomer was isolated from the racemic base. The two enantiomers were examined by the parameters of the antidepressive action specific for pyrazidole. There was no significant difference in the activity of pyrazidole enantiomers. The (+)-enantiomer was found to be less toxic than its antipode.
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页码：4 / 7
页数：4
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