PYRAZIDOLE ENANTIOMERS - PREPARATION AND PHARMACOLOGICAL PROPERTIES

被引：0

作者：

ANDREYEVA, NI

BOGDANOVA, GA

BOKANOV, AI

IVANOV, PY

MASHKOVSKY, MD

SHVEDOV, VI

机构：

来源：

KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1992年 / 26卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The asymmetric synthesis of pyrazidole (+)-enantiomer was made. A pyrazidole (-)-enantiomer was isolated from the racemic base. The two enantiomers were examined by the parameters of the antidepressive action specific for pyrazidole. There was no significant difference in the activity of pyrazidole enantiomers. The (+)-enantiomer was found to be less toxic than its antipode.

引用

页码：4 / 7

页数：4

共 50 条

[1] COMPARISON OF PHARMACOLOGICAL PROPERTIES OF CYCLOPHOSPHAMIDE AND ITS ENANTIOMERS
KLEINROK, Z
CHMIELEWSKA, B
CZUCZWAR, JS
KOZICKA, M
RAJTAR, G
JARZABEK, G
SAWINIEC, Z
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 1986, 34 (03) : 263 - 273
[2] Different pharmacological properties of two enantiomers in a unique β-blocker, nebivolol
Ignarro, Louis J.
CARDIOVASCULAR THERAPEUTICS, 2008, 26 (02) : 115 - 134
[3] SYNTHESIS, ANTIBACTERIAL ACTIVITIES, AND PHARMACOLOGICAL PROPERTIES OF ENANTIOMERS OF TEMAFLOXACIN HYDROCHLORIDE
CHU, DTW
NORDEEN, CW
HARDY, DJ
SWANSON, RN
GIARDINA, WJ
PERNET, AG
PLATTNER, JJ
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 168 - 174
[4] PHARMACOLOGICAL AND REINFORCING PROPERTIES OF PHENCYCLIDINE AND THE ENANTIOMERS OF N-ALLYLNORMETAZOCINE IN THE DOG
VAUPEL, DB
RISNER, ME
SHANNON, HE
DRUG AND ALCOHOL DEPENDENCE, 1986, 18 (02) : 173 - 194
[5] PHARMACOLOGICAL PROPERTIES OF VEINOSCLEROSING PREPARATION OLEOCID
KHADZHAI, YI
CHAIKA, LA
ZHOLUDEV.VI
FARMAKOLOGIYA I TOKSIKOLOGIYA, 1974, 37 (05): : 567 - 570
[6] BROMODERIVATIVES OF GRAMINES - PREPARATION AND PHARMACOLOGICAL PROPERTIES
DASETTIMO, A
PRIMOFIORE, G
FERRARINI, PL
FRANZONE, JS
CIRILLO, R
CRAVANZOLA, C
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1983, 18 (03) : 261 - 267
[7] PREPARATION AND PHARMACOLOGICAL EVALUATION OF ENANTIOMERS OF CERTAIN NONOXYGENATED APORPHINES - (+)- AND (-)-APORPHINE AND (+)- AND (-)-10-METHYLAPORPHINE
CANNON, JG
RAGHUPATHI, R
MOE, ST
JOHNSON, AK
LONG, JP
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (10) : 1316 - 1318
[8] The sodium salt of the enantiomers of ricobendazole: Preparation, solubility and chiroptical properties
Cirilli, Roberto
Guglielmi, Paolo
Formica, Francesca Romana
Casulli, Adriano
Carradori, Simone
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 139 : 1 - 7
[9] PREPARATION AND PHARMACOLOGICAL PROPERTIES OF PSI-CORBASIL
FARRUGIA, MT
HUNTER, WH
KIRK, G
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1969, S 21 : S199 - &
[10] PREPARATION AND PHARMACOLOGICAL PROPERTIES OF THE ACID SUCCINATE OF MYANESIN
RILEY, RF
BERGER, FM
FEDERATION PROCEEDINGS, 1949, 8 (01) : 328 - 328

← 1 2 3 4 5 →