URINARY HYDROXYPROLINE AND SERUM ALKALINE-PHOSPHATASE IN SICKLE-CELL DISEASE

被引：10
作者：
MOHAMMED, SM
SULEIMAN, SA
ADDAE, SK
ANNOBIL, SH
ADZAKU, FK
KADOUMMI, OF
RICHARDS, JT
机构：
[1] KING SAUD UNIV,COLL MED,DEPT CLIN BIOCHEM,RIYADH,SAUDI ARABIA
[2] KING SAUD UNIV,COLL MED,DEPT PHYSIOL,RIYADH,SAUDI ARABIA
[3] KING SAUD UNIV,COLL MED,DEPT PEDIAT,RIYADH,SAUDI ARABIA
来源：
CLINICA CHIMICA ACTA | 1991年 / 203卷 / 2-3期
关键词：
HYDROXYPROLINE; ALKALINE PHOSPHATASE; ISOENZYME; SICKLE CELL DISEASE; SAUDI ARABIA;
D O I：
10.1016/0009-8981(91)90301-R
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Serum alkaline phosphatase, alkaline phosphatase isoenzymes, and urinary hydroxyproline excretion were studied in 20 young adult sickle cell patients and 58 matching normal controls. Total alkaline phosphatase was significantly higher in the sickle cell patients than in controls. Heat inactivation test and isoenzyme electrophoresis indicated that bone is the predominant isoenzyme in patients. Hydroxyproline excretion was significantly higher in the sickle cell patients than in controls. Serum total alkaline phosphatase correlated well with urinary hydroxyproline excretion in sickle cell patients (r = 0.73). Both alkaline phosphatase and hydroxyproline increased with age in the sickle cell patients. This study suggests that delayed growth and/or bone destruction may contribute to the elevated levels of alkaline phosphatase and urinary hydroxyproline.
引用
收藏
页码：285 / 294
页数：10
相关论文
共 27 条
[1]  
ALLISON DJ, 1966, CLIN CHIM ACTA, V141, P729
[2]  
ANDERSON J, 1965, CLIN SCI, V29, P583
[3]   HEIGHTS, WEIGHTS, AND SKELETAL AGE OF JAMAICAN ADOLESCENTS WITH SICKLE-CELL ANEMIA [J].
ASHCROFT, MT ;
SERJEANT, GR ;
DESAI, P .
ARCHIVES OF DISEASE IN CHILDHOOD, 1972, 47 (254) :519-&
[4]  
Bergman I, 1970, Clin Chim Acta, V27, P347, DOI 10.1016/0009-8981(70)90355-4
[5]   SERUM ALKALINE-PHOSPHATASE ISOENZYMES IN SICKLE-CELL ANEMIA [J].
BRODY, JI ;
RYAN, WN ;
HAIDAR, MA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 232 (07) :738-741
[6]  
CERDA J J, 1970, Clinica Chimica Acta, V27, P437, DOI 10.1016/0009-8981(70)90296-2
[7]  
CRABBE P, 1965, GASTROENTEROLOGY, V35, P569
[8]  
CRUZ IA, 1982, J NATL MED ASSOC, V74, P1103
[9]   TUBULAR REABSORPTION OF PHOSPHATE IN SICKLE-CELL NEPHROPATHY [J].
DEJONG, PE ;
DEJONGVANDENBERG, LTW ;
VANEPS, LWS .
CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 55 (05) :429-434
[10]  
DIGGS L. W., 1967, CLIN ORTHOP RELATED RES, V52, P119, DOI 10.1097/00003086-196700520-00011
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