EXPRESSION OF RAT PANCREATIC LIPASE GENE IS MODULATED BY A LIPID-RICH DIET AT A TRANSCRIPTIONAL LEVEL

被引：26
|
作者：
WICKER, C
PUIGSERVER, A
机构：
[1] Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, 13402 Marseille Cedex 9
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91953-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The amount of cytoplasmic mRNAs specific for pancreatic lipase and amylase as well as transcription of the corresponding genes were investigated in rats fed a diet containing 25 % sunflower oil. Concentration of lipase mRNA was actually increased by the lipid-rich carbohydrate-low diet and reached a maximum level after 2 days, but further remained constant for at least 10 days. In contrast, about a two-fold decrease in the concentration of pancreatic amylase mRNA was only observed after rats were fed the high-lipid diet for 10 days. Transcription rate measurements on isolated nuclei from pancreatic tissue indicated that the concentration of nascent lipase and amylase transcripts was consistent with a transcriptional regulation of expression of these two genes. © 1990.
引用
收藏
页码：358 / 364
页数：7
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