The Interleukin-6 and Vascular Endothelial Growth Factor in Hematopoietic Stem Cell Transplantation

被引：3
作者：
Azarpira, Negar [1 ]
Dehghani, Mehdi [2 ]
Darai, Masumeh [1 ]
机构：
[1] Shiraz Univ Med Sci, Organ Transplant Res Ctr, Shiraz, Iran
[2] Shiraz Univ Med Sci, Hematol Res Ctr, Shiraz, Iran
来源：
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION | 2012年 / 23卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We studied the correlation between changes in the serum levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) with complications such as acute graft versus host disease (aGVHD), veno-occlusive disease (VOD) or occurrence of infection after hematopoietic stem cell transplantation (HSCT). Serum VEGF and IL-6 levels were sequentially measured by enzyme-linked immunosorbant assay (ELISA) in 35 patients who had undergone HSCT. Serum levels of IL-6 in patients with aGVHD were increased in comparison with patients without aGVHD, but the difference was not statistically significant. Serum levels of VEGF were only increased in patients with aGVHD during the early days after transplantation. No significantly altered levels of IL-6 and VEGF were observed in patients with VOD or sepsis. These results demonstrate that rising levels of VEGF and IL-6 may be good and specific biomarkers for transplant aGVHD.
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页码：521 / 525
页数：5
相关论文
共 19 条
[11]   Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients [J].
Pihusch, M ;
Pihusch, R ;
Fraunberger, P ;
Pihusch, V ;
Andreesen, R ;
Kolb, HJ ;
Holler, E .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2006, 76 (02) :93-101
[12]   Vascular endothelial growth factor expression in human chronic renal allograft rejection [J].
Pilmore, HL ;
Eris, JM ;
Painter, DM ;
Bishop, GA ;
McCaughan, GW .
TRANSPLANTATION, 1999, 67 (06) :929-933
[13]  
PRZEPIORKA D, 1995, BONE MARROW TRANSPL, V15, P825
[14]   Expression patterns of vascular endothelial growth factor in human cardiac allografts: Association with rejection [J].
Reinders, MEJ ;
Fang, JC ;
Wong, W ;
Ganz, P ;
Briscoe, DM .
TRANSPLANTATION, 2003, 76 (01) :224-230
[15]  
Shahbazi M, 2002, J AM SOC NEPHROL, V13, P260, DOI 10.1681/ASN.V131260
[16]   THE RELATIONSHIP OF SERUM IL-6 LEVELS TO ACUTE GRAFT-VERSUS-HOST DISEASE AND HEPATORENAL DISEASE AFTER HUMAN BONE-MARROW TRANSPLANTATION [J].
SYMINGTON, FW ;
SYMINGTON, BE ;
LIU, PY ;
VIGUET, H ;
SANTHANAM, U ;
SEHGAL, PB .
TRANSPLANTATION, 1992, 54 (03) :457-462
[17]   Suppression of allograft responses induced by interleukin-6, which selectively modulates interferon-gamma but not interleukin-2 production [J].
Tomura, M ;
Nakatani, I ;
Murachi, M ;
Tai, XG ;
Toyooka, K ;
Fujiwara, H .
TRANSPLANTATION, 1997, 64 (05) :757-763
[18]   Vascular endothelial growth factor expression in transplanted human hearts [J].
Torry, RJ ;
Labarrere, CA ;
Torry, DS ;
Holt, VJ ;
Faulk, WP .
TRANSPLANTATION, 1995, 60 (12) :1451-1457
[19]   Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation [J].
Visentainer, JEL ;
Lieber, SR ;
Persoli, LBL ;
Vigorito, AC ;
Aranha, FJP ;
Eid, KAD ;
Oliveira, GB ;
Miranda, ECM ;
de Souza, CA .
EXPERIMENTAL HEMATOLOGY, 2003, 31 (11) :1044-1050
12