The Interleukin-6 and Vascular Endothelial Growth Factor in Hematopoietic Stem Cell Transplantation

被引：3
作者：
Azarpira, Negar [1 ]
Dehghani, Mehdi [2 ]
Darai, Masumeh [1 ]
机构：
[1] Shiraz Univ Med Sci, Organ Transplant Res Ctr, Shiraz, Iran
[2] Shiraz Univ Med Sci, Hematol Res Ctr, Shiraz, Iran
来源：
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION | 2012年 / 23卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We studied the correlation between changes in the serum levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) with complications such as acute graft versus host disease (aGVHD), veno-occlusive disease (VOD) or occurrence of infection after hematopoietic stem cell transplantation (HSCT). Serum VEGF and IL-6 levels were sequentially measured by enzyme-linked immunosorbant assay (ELISA) in 35 patients who had undergone HSCT. Serum levels of IL-6 in patients with aGVHD were increased in comparison with patients without aGVHD, but the difference was not statistically significant. Serum levels of VEGF were only increased in patients with aGVHD during the early days after transplantation. No significantly altered levels of IL-6 and VEGF were observed in patients with VOD or sepsis. These results demonstrate that rising levels of VEGF and IL-6 may be good and specific biomarkers for transplant aGVHD.
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页码：521 / 525
页数：5
相关论文
共 19 条
[1]   Association of IL6 and CCL2 gene polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation [J].
Ambruzova, Z. ;
Mrazek, F. ;
Raida, L. ;
Jindra, P. ;
Vidan-Jeras, B. ;
Faber, E. ;
Pretnar, J. ;
Indrak, K. ;
Petrek, M. .
BONE MARROW TRANSPLANTATION, 2009, 44 (04) :227-235
[2]   THE RELATION OF INTERLEUKIN-6, TUMOR-NECROSIS-FACTOR-ALPHA, IL-2, AND IL-2 RECEPTOR LEVELS TO CELLULAR REJECTION, ALLOGRAFT DYSFUNCTION, AND CLINICAL EVENTS EARLY AFTER CARDIAC TRANSPLANTATION [J].
DENG, MC ;
ERREN, M ;
KAMMERLING, L ;
GUNTHER, F ;
KERBER, S ;
FAHRENKAMP, A ;
ASSMANN, G ;
BREITHARDT, G ;
SCHELD, HH .
TRANSPLANTATION, 1995, 60 (10) :1118-1124
[3]  
Ferrara N, 2000, RECENT PROG HORM RES, V55, P15
[4]   VENOOCCLUSIVE DISEASE OF THE LIVER FOLLOWING BONE-MARROW TRANSPLANTATION [J].
JONES, RJ ;
LEE, KSK ;
BESCHORNER, WE ;
VOGEL, VG ;
GROCHOW, LB ;
BRAINE, HG ;
VOGELSANG, GB ;
SENSENBRENNER, LL ;
SANTOS, GW ;
SARAL, R .
TRANSPLANTATION, 1987, 44 (06) :778-783
[5]   Vascular Endothelial Growth Factor Gene Polymorphisms May Predict the Risk of Acute Graft-versus-Host Disease following Allogeneic Transplantation: Preventive Effect of Vascular Endothelial Growth Factor Gene on Acute Graft-versus-Host Disease [J].
Kim, Dong Hwan ;
Lee, Nan Young ;
Lee, Myung-Hoon ;
Sohn, Song Kyun .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (12) :1408-1416
[6]   Cytokine profiles in stem cell transplantation: Possible use as a predictor of graft-versus-host disease [J].
Lunn, RA ;
Sumar, N ;
Bansal, AS ;
Treleaven, J .
HEMATOLOGY, 2005, 10 (02) :107-114
[7]   Vascular endothelial growth factor in chronic rat allograft nephropathy [J].
Malmstrom, Niina K. ;
Kallio, Erkki A. ;
Rintala, Jukka M. ;
Nykanen, Antti I. ;
Raisanen-Sokolowski, Anne K. ;
Paavonen, Timo ;
Lemstrom, Karl B. ;
Koskinen, Petri K. .
TRANSPLANT IMMUNOLOGY, 2008, 19 (02) :136-144
[8]   Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo [J].
Melter, M ;
Reinders, MEJ ;
Sho, M ;
Pal, S ;
Geehan, C ;
Denton, MD ;
Mukhopadhyay, D ;
Briscoe, DM .
BLOOD, 2000, 96 (12) :3801-3808
[9]   Vascular endothelial growth factor (VEGF) is associated with reduced severity of acute graft-versus-host disease and nonrelapse mortality after allogeneic stem cell transplantation [J].
Min, C-K ;
Kim, S. Y. ;
Lee, M. J. ;
Eom, K. S. ;
Kim, Y. J. ;
Kim, H. J. ;
Lee, S. ;
Cho, S. G. ;
Kim, D. W. ;
Lee, J. W. ;
Min, W. S. ;
Kim, C. C. ;
Cho, C. S. .
BONE MARROW TRANSPLANTATION, 2006, 38 (02) :149-156
[10]   Elevated levels of serum interleukin-6 are associated with low grade cellular rejection in patients with heart transplantation [J].
Perez-Villa, F. ;
Benito, B. ;
Llancaqueo, M. ;
Cuppoletti, A. ;
Roig, E. .
TRANSPLANTATION PROCEEDINGS, 2006, 38 (09) :3012-3015
12