SYNTHESIS, STRUCTURE, AND BIOLOGICAL-ACTIVITY OF ORGANOTIN COMPOUNDS WITH DI-2-PYRIDYLKETONE AND PHENYL(2-PYRIDYL) KETONE 2-AMINOBENZOYLHYDRAZONES

被引：30
作者：
IANELLI, S
MAZZA, P
ORCESI, M
PELIZZI, C
PELIZZI, G
ZANI, F
机构：
[1] UNIV PARMA,DIPARTIMENTO CHIM GEN & INORGAN CHIM ANALIT CHIM,I-43100 PARMA,ITALY
[2] UNIV PARMA,DIPARTIMENTO FARMACEUT,I-43100 PARMA,ITALY
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 1995年 / 60卷 / 02期
关键词：
D O I：
10.1016/0162-0134(95)00005-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ligand behavior of di-2-pyridylketone 2-aminobenzoylhydrazone (Hdpa), and phenyl(2-pyridyl)ketone 2-aminobenzoylhydrazone (Hdba) towards organotin derivatives was investigated. The synthesis and the IR and Sn-119 NMR spectroscopic characterization of the compounds is reported, together with the X-ray crystal structures of Hdpa and Sn(C6H5)(3)Cl(OH2). Hdpa, which are discussed and compared. The in vitro evaluation of antimicrobial properties revealed the strong activity of Sn(C6H5)(2)(Hdpa)Cl-2 and Sn(C6H5)(3)Cl(OH2). Hdpa complexes. None of the compounds showed genotoxicity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.
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页码：89 / 108
页数：20
相关论文
共 22 条
[1]   ORGANOTIN COMPOUNDS .33. THE 1ST COMPLEX-FORMATION BETWEEN ORGANOTIN AND NITRO-DERIVATIVES - REACTIONS OF THE TIN-ALKYL BOND [J].
ALALLAF, TAK ;
KOBS, U ;
NEUMANN, WP .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1989, 373 (01) :29-35
[2]   CHEMICAL-STRUCTURE, SALMONELLA MUTAGENICITY AND EXTENT OF CARCINOGENICITY AS INDICATORS OF GENOTOXIC CARCINOGENESIS AMONG 222 CHEMICALS TESTED IN RODENTS BY THE UNITED-STATES NCI/NTP [J].
ASHBY, J ;
TENNANT, RW .
MUTATION RESEARCH, 1988, 204 (01) :17-115
[3]   EASY ACCESS TO A NEW CLASS OF ANIONIC CYANO-BRIDGED DINUCLEAR AND TRINUCLEAR ORGANOTIN ADDUCTS - CRYSTAL-STRUCTURE OF [N(PPH3)2][CLPH3SN(MU-NC)AG(CN)] [J].
CARCELLI, M ;
FERRARI, C ;
PELIZZI, C ;
PELIZZI, G ;
PREDIERI, G ;
SOLINAS, C .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1992, (13) :2127-2128
[4]  
CARCELLI M, 1995, J ORGANOMET CHEM, V88, P55
[5]   MICROBIAL TRANSFORMATIONS OF TIN AND TIN-COMPOUNDS [J].
COONEY, JJ .
JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1988, 3 (04) :195-204
[6]   TOXIC EFFECTS OF TIN-COMPOUNDS ON MICROORGANISMS [J].
COONEY, JJ ;
WUERTZ, S .
JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1989, 4 (05) :375-402
[7]   STRUCTURE OF A 7-COORDINATED TIN(IV) HYDRAZONE COMPLEX [J].
DELLEDONNE, D ;
PELIZZI, G ;
PELIZZI, C .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1987, 43 :1502-1505
[8]   THE MUTAGENICITY OF ORGANOTIN COMPOUNDS AS ENVIRONMENTAL-POLLUTANTS [J].
HAMASAKI, T ;
SATO, T ;
NAGASE, H ;
KITO, H .
MUTATION RESEARCH, 1993, 300 (3-4) :265-271
[9]   SN-119 NMR IN COORDINATION CHEMISTRY [J].
HANI, R ;
GEANANGEL, RA .
COORDINATION CHEMISTRY REVIEWS, 1982, 44 (02) :229-246
[10]   VERSATILE LIGAND BEHAVIOR OF DI-2-PYRIDYLKETONE 2-AMINOBENZOYLHYDRAZONE (HDPA) TOWARDS SNPH2CL2 - CRYSTAL-STRUCTURES OF [SNPH2(HDPA)CL2] AND [SNPH(DPA)CL2] [J].
IANELLI, S ;
ORCESI, M ;
PELIZZI, C ;
PELIZZI, G ;
PREDIERI, G .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1993, 451 (1-2) :59-65
123