Studies show that improving a patient's Lipid profile may help to prevent or alter the course of coronary artery disease. In addition to bile acid sequestrants, nicotinic acid, fibrates, HMG-CoA reductase inhibitors, and probucol, estrogens and omega-3 fatty acids also have shown benefits in lipid, modification. In choosing among these agents, the practitioner should consider their relative potency and costs, as well as the type of lipid disorder and, the patient's needs and wishes.