INVOLVEMENT OF OXYGEN RADICALS IN THE DIFFERENTIATION OF RAT MYELOMONOCYTIC LEUKEMIA-CELLS IN-VITRO AND IN-VIVO

被引：4

作者：

KOBAYASHI, M

NISHIHARA, J

FUJII, Y

MAEDA, H

HOSOKAWA, M

TAKEICHI, N

机构：

[1] HOKKAIDO UNIV,SCH MED,INST CANC,CELL BIOL LAB,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT BIOCHEM,SAPPORO,HOKKAIDO 060,JAPAN

[3] HOKKAIDO UNIV,SCH MED,DEPT INTERNAL MED 3,SAPPORO,HOKKAIDO 060,JAPAN

[4] KUMAMOTO UNIV,SCH MED,DEPT MICROBIOL,KUMAMOTO 860,JAPAN

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 03期

关键词：

DIFFERENTIATION; OXYGEN RADICAL; LIPOPOLYSACCHARIDE; LEUKEMIA;

D O I：

10.1016/0145-2126(94)90115-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have found that LPS induces the differentiation of an LPS-resistant subline (LR) of a rat myelomonocytic leukemia cell line, c-WRT-7, in vivo, which are resistant to the differentiation inducing effects of LPS in vitro. Furthermore, we have found that the differentiation of LR cells induced by LPS is inhibited by superoxide dismutase, which is one of radical scavengers. Accordingly, we have examined the differentiation inducing effects of xanthin oxidase, a potential source of oxygen radicals, on LR cells in vitro and in vivo. Xanthin oxidase induced the differentiation of LR cells into macrophage-like cells in vitro; and superoxide dismutase inhibited the differentiation of LR cells induced by xanthin oxidase both in vitro and in vivo. These results suggest that oxygen radicals are involved in the differentiation inducing effects of LPS.

引用

页码：199 / 203

页数：5

共 20 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].