SALVAGE OF INFARCTED MYOCARDIUM BY ANGIOGENIC ACTION OF BASIC FIBROBLAST GROWTH-FACTOR

被引：423

作者：

YANAGISAWAMIWA, A

UCHIDA, Y

NAKAMURA, F

TOMARU, T

KIDO, H

KAMIJO, T

SUGIMOTO, T

KAJI, K

UTSUYAMA, M

KURASHIMA, C

ITO, H

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, ENDOCRINOL & METAB SECT, ITABASHI KU, TOKYO 173, JAPAN

[2] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT PATHOL, ITABASHI KU, TOKYO 173, JAPAN

[3] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT BIOCHEM ISOTOPES, ITABASHI KU, TOKYO 173, JAPAN

来源：

SCIENCE | 1992年 / 257卷 / 5075期

关键词：

D O I：

10.1126/science.1382313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate collateral formation are expected to have ameliorating effects on myocardial infarction. In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. Treatment with bFGF increased the number of arterioles and capillaries in the infarct. Thus, the angiogenic action of bFGF might lead to a reduction in infarct size. The application of bFGF might bring about a therapeutic modality for the salvage of infarcted myocardium.

引用

页码：1401 / 1403

页数：3

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