VULNERABILITY OF THE HIPPOCAMPUS TO KAINATE EXCITOTOXICITY IN THE AGED, MATURE AND YOUNG-ADULT RAT

被引:46
作者
KESSLAK, JP
YUAN, D
NEEPER, S
COTMAN, CW
机构
[1] UNIV CALIF IRVINE,DEPT NEUROL,IRVINE,CA 92717
[2] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717
关键词
HIPPOCAMPUS; AGING; KAINIC ACID; EXCITATORY AMINO ACIDS; DEMENTIA;
D O I
10.1016/0304-3940(95)11415-S
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sensitivity to excitotoxic damage was assessed in young adult, mature and aged male Sprague-Dawley rats. Kainic acid was injected into the hippocampus and the size of the hippocampal lesion rated. Intrahippocampal injection of kainic acid produced lesions in aged animals that were significantly smaller than lesions in the young rats (P < 0.05), while lesion size in mature rats was intermediate. Excitotoxic damage was localized primarily to the CA3 region of the hippocampus in the aged rats. Young adult rats had more damage to the hippocampus with involvement of CA1 pyramidal and dentate granule cells. These results suggest that increased age may reduce susceptibility to excitotoxic damage.
引用
收藏
页码:117 / 120
页数:4
相关论文
共 22 条
  • [1] MECHANISMS OF EXCITOTOXICITY IN NEUROLOGIC DISEASES
    BEAL, MF
    [J]. FASEB JOURNAL, 1992, 6 (15) : 3338 - 3344
  • [2] THE ROLE OF EPILEPTIC ACTIVITY IN HIPPOCAMPAL AND REMOTE CEREBRAL-LESIONS INDUCED BY KAINIC ACID
    BENARI, Y
    TREMBLAY, E
    OTTERSEN, OP
    MELDRUM, BS
    [J]. BRAIN RESEARCH, 1980, 191 (01) : 79 - 97
  • [3] MESSENGER-RNAS CODING FOR RECEPTORS AND CHANNELS IN THE CEREBRAL-CORTEX OF ADULT AND AGED RATS
    CARPENTER, MK
    PARKER, I
    MILEDI, R
    [J]. MOLECULAR BRAIN RESEARCH, 1992, 13 (1-2): : 1 - 5
  • [4] EXCITOTOXIC CELL-DEATH
    CHOI, DW
    [J]. JOURNAL OF NEUROBIOLOGY, 1992, 23 (09): : 1261 - 1276
  • [5] CLARK AS, 1992, BEHAV NEUROSCI, V106, P324
  • [6] PROGRESS IN FACILITATING THE RECOVERY OF FUNCTION AFTER CENTRAL-NERVOUS-SYSTEM TRAUMA
    COTMAN, CW
    NIETOSAMPEDRO, M
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 457 : 83 - 104
  • [7] COYLE JT, 1983, J NEUROCHEM, V41, P1
  • [8] Cushman A.A., 1986, STEREOTAXIC ATLAS RA
  • [9] KAINIC ACID-INDUCED SEIZURES IN AGED RATS - NEUROCHEMICAL CORRELATES
    DAWSON, R
    WALLACE, DR
    [J]. BRAIN RESEARCH BULLETIN, 1992, 29 (3-4) : 459 - 468
  • [10] THE HIPPOCAMPUS - WHAT DOES IT DO
    EICHENBAUM, H
    OTTO, T
    COHEN, NJ
    [J]. BEHAVIORAL AND NEURAL BIOLOGY, 1992, 57 (01): : 2 - 36