5-FLUOROURACIL, ADRIAMYCIN, AND MITOMYCIN-C IN ADENOCARCINOMA OF THE ESOPHAGUS OR GASTROESOPHAGEAL JUNCTION TUMORS

被引：1

作者：

KHANSUR, T ^{[1
]}

ALLRED, C ^{[1
]}

TAVASSOLI, M ^{[1
]}

机构：

[1] UNIV MISSISSIPPI,SCH MED,DIV ONCOL,JACKSON,MS

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1994年 / 17卷 / 06期

关键词：

ADENOCARCINOMA OF ESOPHAGUS; GASTROESOPHAGEAL JUNCTION TUMORS; ADRIAMYCIN; CHEMOTHERAPY; 5-FLUOROURACIL; MITOMYCIN C;

D O I：

10.1097/00000421-199412000-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We reviewed our results with chemotherapy for adenocarcinoma of the esophagus or gastroesophageal junction tumors in patients treated with 5-fluorouracil, Adriamycin, and mitomycin C (FAM) regimen as developed by MacDonald and colleagues (10) for adenocarcinoma of the stomach. Sixteen patients were treated, 12 with metastatic and 4 with locoregional disease. Responses were seen in 6 of 16 patients (all partial responses), for an overall response rate of 37.5%. The sites of response include liver (3), lung (1), bone (1), and lymph nodes (1). Median duration of response was 7 months. These results with FAM in adenocarcinoma of the esophagus suggest activity similar to that seen in gastric carcinoma. The second-generation chemotherapy combinations effective in gastric carcinoma merit evaluation in this tumor to see if the remission rates could be further improved.

引用

页码：506 / 508

页数：3

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