SYNTHESES OF (S)-(-)-PINDOLOL AND [3'-C-13]-(R)-(-)-PINDOLOL UTILIZING A LANTHANUM-TITHIUM-(R)-BINOL ((R)-LLB) CATALYZED NITROALDOL REACTION

被引：63

作者：

SASAI, H ^{[1
]}

YAMADA, YMA ^{[1
]}

SUZUKI, T ^{[1
]}

SHIBASAKI, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(01)89540-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient sythesis of (-)-pindolol, an effective beta-blocker, has been achieved utilizing a lanthanum-lithium-(R)-BINOL ((R)-LLB) catalyzed nitroaldol reaction as a key step. This methodology was applicable to a synthesis of C-13-labeled (-)-pindolol, which would be useful as a biological tool for tracing the metabolism of beta-blocker and 5-HT1A receptor antagonist. The mechanistic aspects of the LLB catalyzed nitroaldol reaction are also discussed.

引用

页码：12313 / 12318

页数：6

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