BULLOUS ERUPTION OF SYSTEMIC LUPUS-ERYTHEMATOSUS - A CLINICOPATHOLOGICAL STUDY OF 4 CASES

被引：36

作者：

BURROWS, NP

BHOGAL, BS

BLACK, MM

RUSTIN, MHA

ISHIDAYAMAMOTO, A

KIRTSCHIG, G

JONES, RR

机构：

[1] ROYAL FREE HOSP, LONDON, ENGLAND

[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, ST THOMAS HOSP, ST JOHNS INST DERMATOL, LONDON, ENGLAND

[3] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, ST THOMAS HOSP, DEPT CELL PATHOL, LONDON, ENGLAND

[4] SLADE HOSP, OXFORD, ENGLAND

[5] EALING GEN HOSP, DEPT DERMATOL, LONDON, MIDDX, ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1993年 / 128卷 / 03期

关键词：

D O I：

10.1111/j.1365-2133.1993.tb00180.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We describe the clinical, histological and immunopathological features of four female patients with the bullous eruption of systemic lupus erythematosus (bullous SLE). Three patients had circulating anti-basement membrane zone (BMZ) antibodies, and Western blot analysis in two cases revealed binding to type VII collagen. Immunoelectron microscopy in one of these patients demonstrated deposition of antibody in the lamina densa and sublamina densa regions, thus sharing immunopathological features with epidermolysis bullosa acquisita (EBA). The vesiculobullous lesions developed 8 months to 6 years after the initial symptoms of SLE, and cleared promptly with dapsone treatment.

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页码：332 / 338

页数：7

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