ANTINEOPLASTIC EFFECT OF HALOCYNTHIAXANTHIN, A METABOLITE OF FUCOXANTHIN

被引：33

作者：

NISHINO, H

TSUSHIMA, M

MATSUNO, T

TANAKA, Y

OKUZUMI, J

MURAKOSHI, M

SATOMI, Y

TAKAYASU, J

TOKUDA, H

NISHINO, A

IWASHIMA, A

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT NAT PROD RES,YAMASHINA KU,KYOTO 607,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT SURG 1,KYOTO 602,JAPAN

[3] KAGOSHIMA UNIV,FAC FISHERIES,KAGOSHIMA 890,JAPAN

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 05期

关键词：

ANTINEOPLASTIC ACTIVITY; HALOCYNTHIAXANTHIN; NATURAL CAROTENOID;

D O I：

10.1097/00001813-199210000-00008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have reported that fucoxanthin, a natural carotenoid, inhibited the growth of human neuroblastoma GOTO cells. In the present study, we show that a metabolite of fucoxanthin, halocynthiaxanthin, which is isolated from sea squirt Halocynthia roretzi, has a more potent inhibitory effect. Halocynthiaxanthin (5 mug/ml) caused complete suppression of GOTO cell proliferation, whereas fucoxanthin reduced the growth rate by only 88.8% compared with the control, at day 2 after the drug treatment. Furthermore, halocynthiaxanthin also inhibited the growth of other human malignant tumor cells. Thus halocynthiaxanthin seems to be a promising anti-neoplastic agent.

引用

页码：493 / 497

页数：5

共 12 条

[1] INTRACELLULAR DIVALENT-CATION RELEASE IN PANCREATIC ACINAR CELLS DURING STIMULUS-SECRETION COUPLING .1. USE OF CHLOROTETRACYCLINE AS FLUORESCENT-PROBE [J].