THE P53 MDM-2 AUTOREGULATORY FEEDBACK LOOP

被引：1699

作者：

WU, XW ^{[1
]}

BAYLE, JH ^{[1
]}

OLSON, D ^{[1
]}

LEVINE, AJ ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544

来源：

GENES & DEVELOPMENT | 1993年 / 7卷 / 7A期

关键词：

P53; PROTEIN; MDM-2; GENE; AUTOREGULATORY FEEDBACK LOOP;

D O I：

10.1101/gad.7.7a.1126

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53 protein can bind to a set of specific DNA sequences, and this may activate the transcription of genes adjacent to these DNA elements. The mdm-2 gene is shown here to contain a p53 DNA-binding site and a genetically responsive element such that expression of the mdm-2 gene can be regulated by the level of wild-type p53 protein. The mdm-2 protein, in turn, can complex with p53 and decrease its ability to act as a positive transcription factor at the mdm-2 gene-responsive element. In this way, the mdm-2 gene is autoregulated. The p53 protein regulates the mdm-2 gene at the level of transcription, and the mdm-2 protein regulates the p53 protein at the level of its activity. This creates a feedback loop that regulates both the activity of the p53 protein and the expression of the mdm-2 gene.

引用

页码：1126 / 1132

页数：7

共 39 条

[1] ENHANCED BINDING OF A 95-KDA PROTEIN TO P53 IN CELLS UNDERGOING P53-MEDIATED GROWTH ARREST [J].