THE STIMULATORY EFFECT OF PDGF ON VASCULAR SMOOTH-MUSCLE CELL-MIGRATION IS MEDIATED BY THE INDUCTION OF ENDOGENOUS BASIC FGF

被引：78
|
作者：
SATO, Y
HAMANAKA, R
ONO, J
KUWANO, M
RIFKIN, DB
TAKAKI, R
机构：
[1] NYU MED CTR,KAPLAN CANC CTR,DEPT CELL BIOL,NEW YORK,NY 10016
[2] RAYMOND & BEVERLY SACKLER FDN,NEW YORK,NY 10016
[3] MED COLL OITA,DEPT BIOCHEM,OITA 87956,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 03期
关键词：
D O I：
10.1016/0006-291X(91)91557-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The migration of arterial smooth muscle cells from the media to the intima is a crucial event for the development of the atherosclerotic lesion, and platelet derived growth factor (PDGF) is thought to play an important role in this process. Here we report that the spontaneous migration of bovine smooth muscle (BSM) cells is dependent on endogenously produced basic fibroblast growth factor (bFGF). PDGF stimulates the migration of BSM cells and its effect is abolished by affinity purified anti-bFGF antibody. PDGF induces bFGF mRNA in BSM cells. These results indicate that the effect of PDGF on the migration of BSM cells may be mediated by the induction of endogenous bFGF. © 1991.
引用
收藏
页码：1260 / 1266
页数：7
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