PEPTIDOMIMETICS AND THE TEMPLATE APPROACH TO NUCLEATION OF BETA-SHEETS AND ALPHA-HELICES IN PEPTIDES

被引：86
作者：
KEMP, DS
机构：
[1] D. S. Kemp is at the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139
来源：
TRENDS IN BIOTECHNOLOGY | 1990年 / 8卷 / 09期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1016/0167-7799(90)90187-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Introducing structural constraints into engineered analogs of natural proteins is important for defining essential characteristics, such as specificity or stability, of the protein. This may be achieved by the use of peptidomimetics - elements which mimic the structure of natural peptide components, or conformational templates which induce specific structure formation in contiguous peptide sequence. © 1990.
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收藏
页码：249 / 255
页数：7
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