Aortopulmonary fistula associated with endocarditis complicating mechanical aortic valve replacement has been reported but very limited reports of aortopulmonary fistula following native aortic valve endocarditis in the literature. A 60 year old female presented to our hospital with high fever, dyspnea symptoms over two days. We suspect the endocarditis that Staphylococcus aureus was isolated from blood cultures. Echocardiogram and cathaterization showed that severe aortic regurgitation, aortopulmonary fistula. We urgently performed the aortic valve replacement and closure of both side of fistula with the Contegra(R) patch. The patient developed multiorgan failure as a cause of death at postoperative 63 day.