d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties

被引：245

作者：

Tasinato, A ^{[1
]}

Boscoboinik, D ^{[1
]}

Bartoli, GM ^{[1
]}

Maroni, P ^{[1
]}

Azzi, A ^{[1
]}

机构：

[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, CH-3012 BERN, SWITZERLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 26期

关键词：

D O I：

10.1073/pnas.92.26.12190

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

d-alpha-Tocopherol, but not d-beta-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations, d-alpha-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-beta-tocopherol is ineffective, Furthermore d-beta-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol, The negative regulation by d-alpha-tocopherol of PI;C activity appears to be the cause and not the effect of smooth muscle cell growth inhibition, d-alpha-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation, It is concluded that, in vascular smooth muscle cells, d-alpha-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction path,cay regulating cell proliferation.

引用

页码：12190 / 12194

页数：5

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