REPEATED STRESS ENHANCES VASOPRESSIN SYNTHESIS IN CORTICOTROPIN RELEASING-FACTOR NEURONS IN THE PARAVENTRICULAR NUCLEUS

被引：164

作者：

DEGOEIJ, DCE

JEZOVA, D

TILDERS, FJH

机构：

[1] FREE UNIV AMSTERDAM, FAC MED, DEPT PHARMACOL, VAN BOECHORSTSTR 7, 1081 BT AMSTERDAM, NETHERLANDS

[2] SLOVAK ACAD SCI, INST EXPTL ENDOCRINOL, CS-80936 BRATISLAVA, CZECHOSLOVAKIA

来源：

BRAIN RESEARCH | 1992年 / 577卷 / 01期

关键词：

CORTICOTROPIN RELEASING FACTOR; VASOPRESSIN; REPEATED STRESS; PARAVENTRICULAR NUCLEUS; COLOCALIZATION;

D O I：

10.1016/0006-8993(92)90552-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of repeated stress on corticotropin-releasing factor (CRF) and vasopressin (AVP) synthesis in parvocellular neurons of the paraventricular nucleus (PVN) was studied by means of double label immunocytochemistry. Once daily immobilization of male rats for 16 days leads to a 75% increase in the number of CRF immunoreactive neurons, but a 5-fold elevation in the number of AVP containing CRF cell bodies. These results demonstrate that repeated stress activates AVP synthesis in CRF neurons.

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页码：165 / 168

页数：4

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