The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis

被引：20

作者：

Braliou, Georgia G. ^{[1
]}

Grigoriadou, Athina-Maria G. ^{[1
]}

Kontou, Panagiota I. ^{[1
]}

Bagos, Pantelis G. ^{[1
]}

机构：

[1] Univ Thessaly, Dept Comp Sci & Biomed Informat, 2-4 Papasiopoulou Str, Lamia 35100, Greece

来源：

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2014年 / 10卷 / 16期

关键词：

ESRD; CKD; Kidney disease; Angiotensin receptor; Polymorphism; Genetic association;

D O I：

10.1016/j.csbj.2014.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR) as well as the association of A1332G polymorphism of Angiotensin II type 2 Receptor (AGTR2) gene with Vesicoureteral Reflux (VUR). We found that neither AGTR1.1166C, nor AGTR2 A1332G polymorphisms were significantly associated with any of the aforementioned renal diseases, suggesting that they cannot be used as predictive markers in either general or subgroup ethnic populations. (C) 2014 Braliou et al. Published by Elsevier B.V. on behalf of the Research Network of Computational and Structural Biotechnology.

引用

页码：1 / 7

页数：7

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