DIRECT COUPLING OF FUNCTIONALIZED ORGANOLITHIUM COMPOUNDS WITH ARYL AND VINYL HALIDES

被引：35
作者：
BARLUENGA, J
MONTSERRAT, JM
FLOREZ, J
机构：
[1] Departamento de Química Organometálica, Facultad de Química, Universidad de Oviedo
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 22期
关键词：
D O I：
10.1021/jo00074a025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction between beta- and gamma-nitrogen-functionalized and gamma- and epsilon-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37. Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene. The formation of alkyl halides as intermediates has been verified. Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.
引用
收藏
页码：5976 / 5980
页数：5
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