GLUCOCORTICOID-INDUCED APOPTOSIS OF LYMPHOID-CELLS

被引：105
作者：
SCHWARTZMAN, RA
CIDLOWSKI, JA
机构：
[1] UNIV N CAROLINA, DEPT PHYSIOL, CHAPEL HILL, NC 27599 USA
[2] UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, CHAPEL HILL, NC 27599 USA
[3] UNIV N CAROLINA, CARNEGIE INST WASHINGTON, DEPT EMBRYOL, CHAPEL HILL, NC USA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 105卷 / 04期
关键词：
APOPTOSIS; LYMPHOCYTES; GLUCOCORTICOIDS; GLUCOCORTICOID RECEPTOR; ENDONUCLEASES;
D O I：
10.1159/000236781
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis. Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids. The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several once genes in glucocorticoid-induced cell lysis. In addition, the clinical importance of glucocorticoid-induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.
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收藏
页码：347 / 354
页数：8
相关论文
共 103 条
[1]  
ALNEMRI ES, 1992, CANCER RES, V52, P491
[2]  
ARENDS MJ, 1990, AM J PATHOL, V136, P593
[3]  
Barlogie B, 1992, Curr Top Microbiol Immunol, V182, P245
[4]   IDENTIFICATION OF DEOXYRIBONUCLEASE-II AS AN ENDONUCLEASE INVOLVED IN APOPTOSIS [J].
BARRY, MA ;
EASTMAN, A .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (01) :440-450
[5]   GENES NEWLY IDENTIFIED AS REGULATED BY GLUCOCORTICOIDS IN MURINE THYMOCYTES [J].
BAUGHMAN, G ;
HARRIGAN, MT ;
CAMPBELL, NF ;
NURRISH, SJ ;
BOURGEOIS, S .
MOLECULAR ENDOCRINOLOGY, 1991, 5 (05) :637-644
[6]   MOLECULAR-CHANGES ASSOCIATED WITH INDUCTION OF CELL-DEATH IN A HUMAN T-CELL LEUKEMIA LINE - PUTATIVE NUCLEASES IDENTIFIED AS HISTONES [J].
BAXTER, GD ;
SMITH, PJ ;
LAVIN, MF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 162 (01) :30-37
[7]   GLUCOCORTICOID RECEPTORS IN LYMPHOMA CELLS IN CULTURE - RELATIONSHIP TO GLUCOCORTICOID KILLING ACTIVITY [J].
BAXTER, JD ;
TOMKINS, GM ;
HARRIS, AW ;
COHN, M .
SCIENCE, 1971, 171 (3967) :189-&
[8]   INVIVO ACCUMULATION OF SULFATED GLYCOPROTEIN-2 MESSENGER-RNA IN RAT THYMOCYTES UPON DEXAMETHASONE-INDUCED CELL-DEATH [J].
BETTUZZI, S ;
TROIANO, L ;
DAVALLI, P ;
TROPEA, F ;
INGLETTI, MC ;
GRASSILLI, E ;
MONTI, D ;
CORTI, A ;
FRANCESCHI, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :810-815
[9]   APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2 [J].
BISSONNETTE, RP ;
ECHEVERRI, F ;
MAHBOUBI, A ;
GREEN, DR .
NATURE, 1992, 359 (6395) :552-554
[10]   TRANSCRIPTIONAL ANALYSES OF STEROID-REGULATED GENE NETWORKS [J].
BRIEHL, MM ;
FLOMERFELT, FA ;
WU, XP ;
MIESFELD, RL .
MOLECULAR ENDOCRINOLOGY, 1990, 4 (02) :287-294
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