MULTIDOMAIN ENZYMES INVOLVED IN PEPTIDE-SYNTHESIS

被引：91

作者：

MARAHIEL, MA

机构：

来源：

FEBS LETTERS | 1992年 / 307卷 / 01期

关键词：

MULTIDOMAIN ENZYME; PEPTIDE SYNTHETASE; THIO-TEMPLATE; CORE SEQUENCE;

D O I：

10.1016/0014-5793(92)80898-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biosynthesis of peptides in non-ribosomal systems is catalyzed by multifunctional enzymes that employ the thio-template mechanism. Recent studies on the analysis of the primary structure of several peptide synthetases have revealed that they are organized in highly conserved and repeated functional domains. The aligned domains provide the template for peptide synthesis, and their order determines the sequence of the peptide product.

引用

页码：40 / 43

页数：4

共 39 条

[1] A GENE ENCODING LYSINE 6-AMINOTRANSFERASE, WHICH FORMS THE BETA-LACTAM PRECURSOR ALPHA-AMINOADIPIC ACID, IS LOCATED IN THE CLUSTER OF CEPHAMYCIN BIOSYNTHETIC GENES IN NOCARDIA-LACTAMDURANS [J].