EFFECT OF DIAZEPAM ON THE FATTY-ACID COMPOSITION OF PLASMA AND LIVER PHOSPHOLIPIDS IN RAT

被引：5

作者：

RISTIC, V

VRBASKI, SR

机构：

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1992年 / 47卷 / 03期

关键词：

D O I：

10.1016/0885-4505(92)90026-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male Wistar rats (2 months old) were maintained on a nutritionally adequate diet, and diazepam was administered at a dose of 10 mg/kg/day. After 24 weeks the effects on the fatty acid composition of plasma and liver phospholipids were studied. Increased levels of palmitic (16:0), palmitoleic (16:1n-7), stearic (18:0), and oleic (18:1n-9) acids were found in plasma phospholipids. In contrast, the levels of docosapentanoic (22:5n-3) and docosahexanoic (22:6n-3; DHA) acids were drastically decreased by diazepam. A significant decrease produced by diazepam was also found in levels of DHA in liver phospholipids. © 1992.

引用

页码：199 / 204

页数：6

共 22 条

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