MICROBIOLOGICAL TRANSFORMATIONS OF HECOGENIN AND DIOSGENIN BY CUNNINGHAMELLA-ELEGANS

被引：18

作者：

BLUNDEN, G ^{[1
]}

PATEL, AV ^{[1
]}

CRABB, TA ^{[1
]}

机构：

[1] PORTSMOUTH POLYTECH,DEPT CHEM,PORTSMOUTH PO1 2DZ,HANTS,ENGLAND

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 06期

关键词：

(25R)-1β; 3β; 7β-trihydroxy-5α-spirostan-12-one; (25R)-3β; 12β-dihydroxy-spirost5-en-7-one; 7β-dihydroxy-5α-spirostan-; 12-one; (25R)-3β-hydroxy-5α-spirostane-7,12-dione; (25R)-spirost-5-ene-3β; 7β; 12β-triol; Cunninghamella elegans; diosgenin; hecogenin; microbiological transformation; Mucorales; steroidal sapogenins;

D O I：

10.1016/0031-9422(90)85013-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incubation of (25R)-3β-hydroxy-5α-spirostan-12-one (hecogenin) with the fungus Cunninghamella elegans led to the formation of (25R)-1β,3β,7β-trihydroxy-5α-spirostan-12-one, (25R)-3β,7β-dihydroxy-5α-spirostan-12-one and (25R)-3β-hydroxy-5α-spirostane-7,12-dione. Incubation of (25R)-spirost-5-en-3β-ol (diosgenin) with the same fungus gave rise to (25R)-spirost-5-ene-3β,7β,12β-triol and (25R)-3β,12β-dihydroxy-spirost-5-en-7-one. © 1982.

引用

页码：1771 / 1780

页数：10

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