MKP1 mediates resistance to therapy in HER2-positive breast tumors

被引：8
作者：
Candas, Demet [1 ]
Li, Jian Jian [1 ]
机构：
[1] Univ Calif Davis, NCI Designated Comprehens Canc Ctr, Sch Med, Dept Radiat Oncol, Sacramento, CA USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 04期
基金：
美国国家卫生研究院;
关键词：
breast cancer; HER2; mitochondria; MKP1; radioresistance;
D O I：
10.1080/23723556.2014.997518
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
引用
收藏
页数：2
相关论文
共 7 条
  • [1] Mitogen-activated protein (MAP) Kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer
    Boutros, Tarek
    Chevet, Eric
    Metrakos, Peter
    [J]. PHARMACOLOGICAL REVIEWS, 2008, 60 (03) : 261 - 310
  • [2] Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
    Candas, Demet
    Lu, Chung-Ling
    Fan, Ming
    Chuang, Frank Y. S.
    Sweeney, Colleen
    Borowsky, Alexander D.
    Li, Jian Jian
    [J]. CANCER RESEARCH, 2014, 74 (24) : 7498 - 7509
  • [3] HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells
    Duru, Nadire
    Fan, Ming
    Candas, Demet
    Menaa, Cheikh
    Liu, Hsin-Chen
    Nantajit, Danupon
    Wen, Yunfei
    Xiao, Kai
    Eldridge, Angela
    Chromy, Brett A.
    Li, Shiyong
    Spitz, Douglas R.
    Lam, Kit S.
    Wicha, Max S.
    Li, Jian Jian
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (24) : 6634 - 6647
  • [4] Translocation of SAPK/JNK to mitochondria and interaction with Bcl-xL in response to DNA damage
    Kharbanda, S
    Saxena, S
    Yoshida, K
    Pandey, P
    Kaneki, M
    Wang, QZ
    Cheng, K
    Chen, YN
    Campbell, A
    Sudha, T
    Yuan, ZM
    Narula, J
    Weichselbaum, R
    Nalin, C
    Kufe, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) : 322 - 327
  • [5] The biology of human epidermal growth factor receptor 2.
    Sundaresan S.
    Penuel E.
    Sliwkowski M.X.
    [J]. Current Oncology Reports, 1999, 1 (1) : 16 - 22
  • [6] Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer
    Wang, HY
    Cheng, ZY
    Malbon, CC
    [J]. CANCER LETTERS, 2003, 191 (02) : 229 - 237
  • [7] Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-κB regulation
    Wang, Zhaoqing
    Cao, Ning
    Nantajit, Danupon
    Fan, Ming
    Liu, Yusen
    Li, Jian Jian
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (30) : 21011 - 21023
1