Monitoring of acute traumatic brain injury in adults to prevent secondary brain damage

Traumatic brain injury is typically characterized by the primary injury initiating a cascade of pathologic changes that then lead to secondary brain injury. Secondary brain injury is amenable to different therapeutic options. Monitoring of otherwise occult pathologic changes involving oxygenation and metabolism is crucial for treatment decisions. Currently, decision-making is mainly based on measuring intracranial pressure and cerebral perfusion pressure. Importantly, extending neuromonitoring by including parameters reflecting cerebral perfusion, oxygenation and metabolism may improve treatment of traumatic brain injury patients by detecting neuronal damage despite optimal intracranial pressure or cerebral perfusion pressure and preventing unnecessarily aggressive treatment potentially causing local and systemic harm. In this review, the authors describe the advantages and disadvantages of contemporary, extended neuromonitoring methods in traumatic brain injury patients aimed at unmasking secondary brain damage as early as possible.