OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES AND MYELODYSPLASIA - A CASE-CONTROL STUDY

被引：75
|
作者：
WEST, RR
STAFFORD, DA
FARROW, A
JACOBS, A
机构：
[1] University of Wales College of Medicine, Cardiff
来源：
LEUKEMIA RESEARCH | 1995年 / 19卷 / 02期
基金：
英国医学研究理事会;
关键词：
MYELODYSPLASIA; CASE-CONTROL CHEMICALS; RADIATION;
D O I：
10.1016/0145-2126(94)00141-V
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A case-control study of newly diagnosed myelodysplastic syndrome patients investigated lifetime exposures through occupation, environment or hobby by questionnaire, structured and semi-structured interview. The exposure histories of 400 individually matched pairs were compared. Increased or possibly increased odds ratios were observed for radiation (2.05, 95% confidence interval 1.16-3.76), halogenated organics (1.57, 0.97-2.57), metals (1.40, 0.99-2.00), several specific radiation exposures and individual chemicals and for childlessness (1.46, 1.01-2.11). Since myelodysplasia generally carries a poor prognosis, whether or not individuals convert to leukaemia or to other cancer, these findings add to previous reports of exposures implicated in the aetiology of leukaemia and add to the case for minimizing exposures to radiation and halogenated organics.
引用
收藏
页码：127 / 139
页数：13
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