EFFECT OF STARVATION OR STREPTOZOTOCIN-DIABETES ON PHOSPHATE-ACTIVATED GLUTAMINASE OF DIFFERENT RAT-BRAIN REGIONS

被引：2

作者：

LELLOS, V ^{[1
]}

MORAITOU, M ^{[1
]}

TSELENTIS, V ^{[1
]}

PHILIPPIDIS, H ^{[1
]}

PALAIOLOGOS, G ^{[1
]}

机构：

[1] UNIV ATHENS,SCH MED,BIOL CHEM LAB,MIKRAS ASIAS 75,GR-11527 ATHENS,GREECE

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 02期

关键词：

PHOSPHATE-ACTIVATED GLUTAMINASE; BRAIN REGIONS; STREPTOZOTOCIN DIABETES; LONG-TERM STARVATION; INSULIN;

D O I：

10.1007/BF00966791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphate-activated glutaminase (PAG) was assayed in homogenates of brain cerebellum, hippocampus or striatum from normal, starved for 48 h or 120 h or streptozotocin-diabetic rats. Only the hippocampal enzyme was increased (47%) by diabetes. Starvation had no effect in any of the regions studied. PAG of synaptosomes or of non-synaptosomal mitochondria from the hippocampus was also increased by 48% and 22% respectively in diabetes. PAG of synaptosomes from the cortex, the cerebellum, or the striatum or of the non-synaptosomal mitochondria from the cortex were not affected by diabetes or prolonged (120h) starvation. A suggestion is presented that peripheral insulin, indirectly, may regulate PAG activity in a specific region of the rat brain.

引用

页码：141 / 145

页数：5

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