Synthesis of N-((2-Substituted Phenyl)-4, 5-Diphenyl-1H-Imidazol-1yl)(Phenyl)Methyl) substituted amine derivatives, spectral characterization and their pharmacological evaluation

A series of N-((2-substituted phenyl) -4,5-diphenyl-1H-imidazol-1yl)(phenyl) methyl) substituted amine derivatives TPI (I-V) were synthesized by 2-substituted 4,5-diphenyl imidazole derivatives starting from benzyl and aromatic aldehyde. All these compounds were characterized by IR, (HNMR)-H-1, mass and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities by hot plate and carrageenan induced rat paw oedema methods. Compounds TPI-IV and TPI-V have showed potent anti-inflammatory activity and compounds TPI-III, TPI-IV and TPI-V showed good analgesic activity.