ENDOCRINE AGING IN CBA MICE - CHARACTERIZATION OF UTERINE CYTOSOLIC AND NUCLEAR SEX STEROID-RECEPTORS

被引：15
作者：
BELISLE, S [1 ]
BEAUDRY, C [1 ]
LEHOUX, JG [1 ]
机构：
[1] UNIV SHERBROOKE, FAC MED, DEPT BIOCHEM, SHERBROOKE J1K 2R1, QUEBEC, CANADA
来源：
EXPERIMENTAL GERONTOLOGY | 1982年 / 17卷 / 06期
关键词：
D O I：
10.1016/S0531-5565(82)80002-8
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Alterations with age in sex steroid hormone/receptor interaction were examined in the uteri of CBA mice. The mean affinity for estrogens and progesterone observed in uterine cytosols and nuclei of old (16-18 mo.) mice were no different than those observed in young (4-8 mo.) animals. Whereas the total number of unoccupied estrogenic receptor sites in old uteri did not differ significantly from that observed in uteri of young mice, aging was accompanied by a 3-fold and significant decrease in mean nuclear binding sites when standardized as mg of DNA (P < 0.05). Aging uteri showed a 3-fold and significant decrease in the total number of uterine progesterone receptor concentration (P < 0.05) which was manifested by a decrease of progesterone binding sites in the cytosol and the nucleus. Aging CBA mice present a profile of altered hormone-receptor interraction which is only partly dependent on ovarian steroids.
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页码：417 / 423
页数：7
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