SURVIVAL OF INTRACEREBRALLY GRAFTED RAT DOPAMINE NEURONS PREVIOUSLY CULTURED INVITRO

被引：46

作者：

BRUNDIN, P ^{[1
]}

BARBIN, G ^{[1
]}

ISACSON, O ^{[1
]}

MALLAT, M ^{[1
]}

CHAMAK, B ^{[1
]}

PROCHIANTZ, A ^{[1
]}

GAGE, FH ^{[1
]}

BJORKLUND, A ^{[1
]}

机构：

[1] COLL FRANCE, INSERM, U114, GRP NB, F-75231 PARIS 05, FRANCE

来源：

NEUROSCIENCE LETTERS | 1985年 / 61卷 / 1-2期

关键词：

D O I：

10.1016/0304-3940(85)90404-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fetal rat dopamine (DA) neurons were cultured in vitro for a 6-day period and transported, after redisssociation, for 2 days prior to being grafted to the neostriatum of adult rats with 6-hydroxydopamine lesions of the ascending nigrostriatal pathway. In 2 of the 5 graft recipients that were tested for amphetamine-induced motor asymmetry, the grafts eliminated the lesion-induced turning behaviour within 3-6 weeks after transplantation. Fluorescence histochemistry revealed surviving grafts in all 6 recipients at 7 weeks after transplantation, containing between 42 and 125 DA neurons. The number of surviving DA neurons in the 3 non-compensated rats was below the minimum number of cells previously found to be necessary for functional effects on turning behaviour to occur.

引用

页码：79 / 84

页数：6

共 25 条

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