On your marks, get SET(D1A): the race to protect stalled replication forks

被引：6

作者：

Begum, Shabana ^{[1
]}

Goula, Amalia ^{[1
]}

Bayley, Rachel ^{[1
]}

Higgs, Martin R. ^{[1
]}

机构：

[1] Univ Birmingham, Inst Canc & Genom Sci, Lysine Methylat & DNA Damage Lab, Birmingham, W Midlands, England

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 06期

基金：

英国医学研究理事会;

关键词：

Genome stability; SETD1A; FANCD2; replication stress; Chemoresistance; CHD4;

D O I：

10.1080/23723556.2018.1511209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.

引用

页数：3

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