HYPOGLYCEMIC ACTIVITY OF NELUMBO-NUCIFERA GAERTN (FAM NYMPHAEACEAE) RHIZOME (METHANOLIC EXTRACT) IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

被引：27
|
作者：
MUKHERJEE, PK [1 ]
PAL, SK [1 ]
SAHA, K [1 ]
SAHA, BP [1 ]
机构：
[1] JADAVPUR UNIV,DEPT PHARMACEUT TECHNOL,CALCUTTA 700032,W BENGAL,INDIA
来源：
PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 07期
关键词：
NELUMBO NUCIFERA; RHIZOMES; HYPOGLYCEMIC ACTIVITY; STREPTOZOTOCIN-DIABETIC RATS;
D O I：
10.1002/ptr.2650090712
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The hypoglycaemic effect of the rhizome extract of Nelumbo nucifera was studied in streptozotocin-induced diabetic rats. A methanol extract of the plant obtained by soxhlet extraction from finely pulverized rhizomes was used, The LD(50) Of the extract was found to be 2 g/kg, The extract (300 mg/kg and 600 mg/kg, orally) caused a reduction of blood glucose levels in streptozotocin-induced diabetic rats by 53% (p< 0.001) and 55% (p < 0.001) respectively at the end of 12 h, The results of this study indicate that the methanol extract of the rhizome possesses favourable hypoglycaemic activity in hyperglycaemic animals taking chlorpropamide as a standard.
引用
收藏
页码：522 / 524
页数：3
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